Mouse spleen dendritic cells present soluble antigens to antigen- specific T cell hybridomas

نویسندگان

  • G H Sunshine
  • D P Gold
  • H H Wortis
  • P Marrack
  • J W Kappler
چکیده

In the presence of the soluble polypeptide antigens ovalbumin and keyhole limpet hemocyanin, purified mouse spleen dendritic cells induce the secretion of IL-2 by antigen-specific T cell hybridomas. This response is H-2 restricted and can be specifically inhibited by monoclonal anti-I-A. These data indicate that dendritic cells can present soluble antigen to H-2-compatible T cells.

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عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 158  شماره 

صفحات  -

تاریخ انتشار 1983